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Once taken up by neurons, L-lactate is converted back to pyruvate to support the Tricarboxylic Acid (TCA) cycle (20)

Biased agonism describes how different ligands, upon binding to the same receptor, can preferentially stabilize distinct receptor conformations, thereby selectively activating specific downstream signaling pathways (e.g., Gs-cAMP vs

4.2 Acupuncture prevents PD by modulating apoptosis A study demonstrated that electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints exerts neuroprotective effects in 6-hydroxydopamine (6-OHDA)-induced PD model rats through dual regulation of the endoplasmic reticulum stress (ERS) pathway